Leishmanicidal Effect of Synthetic trans-Resveratrol Analogs
نویسندگان
چکیده
منابع مشابه
Leishmanicidal Effect of Synthetic trans-Resveratrol Analogs
BACKGROUND Stilbene-based compounds show antitumoral, antioxidant, antihistaminic, anti-inflammatory and antimicrobial activities. Here, we evaluated the effect of the trans-resveratrol analogs, pterostilbene, piceatannol, polydatin and oxyresveratrol, against Leishmania amazonensis. METHODOLOGY/PRINCIPAL FINDINGS Our results demonstrated a low murine macrophage cytotoxicity of all four analo...
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A reversed-phase high-performance liquid chromatography method with diode array detection was developed for the determination of trans- and cis-resveratrol in red wines. Separation was achieved after direct injection by the use of a BDS Hypersil C18 column (250 × 4.6 mm) with gradient elution (solvent A: acetic acid 2%, solvent B: acetonitrile). Detection of trans- and cis-resveratrol was perfo...
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Epidemiological evidence indicates that nutritionally-derived polyphenols such as resveratrol (RES) have neuroprotective properties. Administration of RES to culture media protects a wide variety of neuronal cell types from stress-induced death. Dietary supplementation of RES can ameliorate neuronal damage and death resulting from both acute and chronic stresses in rodents. The specific molecul...
متن کاملLeishmanicidal activities of novel synthetic furoxan and benzofuroxan derivatives.
A novel series of furoxan (1,2,5-oxadiazole 2-oxide) (compounds 3, 4a and -b, 13a and -b, and 14a to -f) and benzofuroxan (benzo[c][1,2,5]oxadiazole 1-oxide) (compounds 7 and 8a to -c) derivatives were synthesized, characterized, and evaluated for in vitro activity against promastigote and intracellular amastigote forms of Leishmania amazonensis. The furoxan derivatives exhibited the ability to...
متن کاملPhotochemical and photocatalytic degradation of trans-resveratrol.
Photochemical and photocatalytic degradation of the emerging pollutant trans-resveratrol has been studied under different irradiation wavelengths and using different TiO2 catalysts. trans-Resveratrol was more easily degraded when irradiated using the whole spectral range (UV-Vis) rather than with UV and near-UV to visible irradiation. The main intermediate of trans-resveratrol phototransformati...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0141778